Since in our study male and female H-AMPKα1 WT mice exhibited similar organ injury and outcomes after sepsis, we speculate that the differential hormonal milieu between male and female may, indeed, result in a diversification of mitochondria quality control during acute stress only in condition of dysregulation of AMPKα1 and the level of expression per se of this enzyme is most likely a key element for sex-dependent switch of metabolic regulation. Here, PRKAA1 is linked to Sepsis.