As AMPKα1 is abundantly expressed in the liver of rodents and the predominant isoform in human hepatocytes (11, 12, 17), we sought to investigate the role of the hepatocyte AMPKα1 on sepsis-induced liver injury and mortality by employing hepatocyte-specific AMPKα1 knockout (H-AMPKα1 KO) young male mice (18). This evidence concerns the gene PRKAA1 and Sepsis.