IL1B and acute respiratory distress syndrome: Second, while we demonstrated the crucial involvement of IL-1β in the development of VILI/ALI by treating mice with anti-IL-1β mAb at the same point as LPS administration, we did not test the effect of late administration of anti-IL-1β mAb (i.e., anti-IL-1β antibody administration after LPS treatment) from a translational point of view.