Exploring the role of c-Maf in three different disease models, each characterized by the predominant activity of a different T helper cell subset [malaria—Th1 cells; allergy to house dust mite—Th2 cells; experimental autoimmune encephalitis (EAE)—Th17 cells], Gabryšová et al. recently reported that Il10 expression was significantly lower in the absence of c-Maf, in T helper cells across all three diseases (67). Here, MAF is linked to allergic disease.