In this study, malnutrition resulted in decreased HRV-specific IgA and IgG antibodies in serum, intestinal contents, and decreased HRV-specific IgA and IgG ASCs in blood, and intestinal tissues (except HRV-specific IgG and IgA ASCs in duodenum), indicating an impaired mucosal and systemic HRV antibody response following VirHRV challenge. Here, CD79A is linked to nutritional deficiency disease.