In line with this, we found decreased DNA methylation of two DMPs within UBASH3A in CD4+ memory T cells in MTX treated RA patients compared to controls, presumably leading to increased expression of UBASH3A. Interestingly, the autoimmune risk variant at rs1893592 in UBASH3A is associated with decreased lymphocyte percentage in the UK biobank cohort (38). This evidence concerns the gene CD4 and rheumatoid arthritis.