IRF8 and rheumatoid arthritis: However, both the DMP and risk SNP pointed toward the same gene for PTPN2, IRF8, UBASH3A, TRAF1, CD83, and FCGR2A. In addition, the RA risk SNP (rs1893592) is located in intron 1 of UBASH3A, while the two DMPs detected in our study mapped to intron 4 and 14 of UBASH3A (Supplementary Table 4).