UBASH3A and rheumatoid arthritis: One third of the known RA risk SNPs were located in the vicinity of our DMPs, and one of the most robust findings was for UBASH3A. Nevertheless, larger studies of homogenous RA patients and controls comprising bisulfite sequencing of relevant immune cell subsets are necessary to further establish the changes in DNA methylation that play a part in RA pathogenesis, drug response and disease development before the putative role of epigenetic factors can be assessed in a clinical setting.