CD4 and colitis: Lastly, in contrast to our previous work revealing a role for IFN-γ producing CD4+ and CD8+ T cells in mediating colitis susceptibility in global Mbd2 deficient mice (6), the total number of colon LP CD4+ or CD8+ T cells and colon IFN-γ mRNA expression were equivalent between DSS treated CD11cΔMbd2 mice and controls (Figures 4J,K), suggesting increased colitis susceptibility was T cell independent in this context.