In addition, we have shown that Mbd2 deficient intestinal T cells over-express IFN-γ in experimental colitis (6), that Mbd2 deficient mice develop chronic intestinal inflammation after a single mucosal injury (6), and Mbd2 deficient dendritic cells (DCs) are less able to initiate immune responses (2). The gene discussed is MBD2; the disease is colitis.