HAVCR2 and acute myeloid leukemia: TIM-3 engagement with Gal-9 was able to induce IFN-y production by NK cells with no effect on cytotoxic ability (251), and anti-Gal-9 antibody blockade of TIM-3 reduced the production of IFN-γ by NK cells from healthy donors in response to primary AML blasts (231).