However, aberrant expression of B7-H3 is seen in various malignancies in which it is associated with poor outcome, including RCC, breast cancer, lung cancer, esophageal squamous cancer, gastric cancer, pancreatic cancer, gallbladder cancer, colorectal cancer, prostate cancer, ovarian cancer, cervical cancer, endometrial cancer, osteosarcoma, and neuroblastoma (358, 359). This evidence concerns the gene CD276 and lung carcinoma.