We found that MCAO significantly enhanced the expression of CD86 and inhibited that of CD206, in ischemic infarction (Figure 1D), ischemic penumbra (Figure 1E), and hippocampus (Figure 1F) in the ischemic brain hemisphere, suggesting neuroinflammation is induced by focal cerebral ischemia. This evidence concerns the gene MRC1 and Cerebral ischemia.