C3 and choroidal neovascularization: Bora et al. in 2005, reported C3 and MAC complex depositions in neovessels in mice model of laser-induced choroidal neovascularization (CNV), while the C3 knock out (C3−/−) CNV mice showed an absence of neovascularization, with a reduced level of angiogenic factors, thereby suggesting complement component C3 as a pro-angiogenic factor (15).