CD40LG and activated PI3K-delta syndrome: Dominant mutations in PI3KCD is now known as activated PI3Kδ syndrome (APDS), and some subjects may present with a CVID-like or hyper-IgM phenotype, with recurrent sinopulmonary infections, reduced IgG in 43%, reduced IgA in 50%, and increased IgM in 79% of subjects (48–51).