Since placenta and tumors share common features, i.e., invasiveness, high degrees of cell turnover, requirement for angiogenesis, immune regulation to suppress the adaptive immune response to allo-/tumor-antigens, we propose that PP13 could shift neutrophils toward a placental-growth-permissive phenotype, recalling the one observed in cancer while maintaining all their primary functions and abilities to respond to bacterial invasion. This evidence concerns the gene LGALS13 and cancer.