Recurrently mutated gene in hematologic malignancies that are likely to produce semi-personal rather than shared neoantigens include Wilms tumor 1 (WT1) in AML (91–94) and T cell ALL (95), Notch1 and FBXW7 in T cell ALL (96–98), and TP53 in multiple malignancies (99–101). The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.