Although IFN-γ and IL-17A were abundantly secreted by blood cells of LTBI donors independent of age (multiple R-squared derived by linear models: 0.1037 and 0.4192, for IFN-γ and IL-17, respectively), differences in IP-10 responses between LTBI and TB were less marked in adolescents (multiple R-squared derived by linear models: 0.009575) (Figure 2B, upper plots). This evidence concerns the gene IFNG and tuberculosis.