To determine how TRPM2 channel modulates the innate inflammatory response induced against L. monocytogenes infection, we infected C57BL/6 (WT), Trpm2−/− or Ccr2−/− mice with a sublethal dose of L. monocytogenes (104 CFU) and evaluated the susceptibility of Trpm2−/− mice to infection. Here, TRPM2 is linked to infection.