Similar exacerbated inflammatory response was already observed in the Trpm2−/− mice by our group, in a model of gastric infection by H. pylori infection (14), and by other investigators using distinct models of infection including, lung infection induced by P. aeruginosa (38), sepsis-induced by E. coli (49) or polymicrobial sepsis (50). This evidence concerns the gene TRPM2 and infection.