By contrast, another study reports that MFG-E8 levels are low in liver and serum from patients with cirrhosis, and that administration of mesenchymal stem cell-derived MFG-E8 alleviates liver fibrosis in mice by suppressing expression of TGF-βR1 by binding to αvβ3 integrin (50). This evidence concerns the gene TGFBR1 and Hepatic fibrosis.