Therefore, to test if overexpression of BMP7 can promote a T cell-cold state, we exogenously expressed BMP7 in murine 4T1-S (breast) and MC38 (colon) cancer cells (both of which lack endogenous BMP7 expression) and studied the in vivo effects of BMP7 on intratumoral CD8+ T cell abundance. Here, BMP7 is linked to cancer.