Interestingly, no difference in tumor growth was observed between the BMP7-expressing and control tumor groups of the 4T1-S model (Supplementary Figure 11), and BMP7 expression in the MC38 model did not decrease the efficacy of anti-PD-L1, but rather, in a somewhat paradoxical fashion, the combination of BMP7 expression and anti-PD-L1 resulted in a significant reduction of tumor growth (Supplementary Figures 12B,C). This evidence concerns the gene BMP7 and neoplasm.