ULBP2 and neoplasm: In the context of tumor-immunosurveillance, pADAM10 has not only been identified as sheddase of canonical substrates on platelets, but also to be involved in cleavage of the stress-induced NKG2D ligands (NKG2DL) MICA, MICB and ULBP2 from the surface of tumor cells (118, 119) (Figure 1B).