The GO term enrichment analysis results suggested that PTPN2 encodes T-cell protein tyrosine phosphatase, acting as a negative regulator of the JAK/STAT signaling pathways downstream of cytokines and playing a prominent role in T-cell activation, signaling and/or effector function, which may represent potential targets for the pharmacotherapy of autoimmune diseases. Here, PTPN2 is linked to autoimmune disease.