The role of TNF signaling was also evident in the results; the herpesvirus entry mediator (HVEM), a member of the TNF receptor superfamily, is expressed on T-cells, and soluble LTBR protein has been shown to compete with HVEM receptor to inhibit T-cell activity and prevent GvHD in murine models. The gene discussed is TNFRSF14; the disease is graft versus host disease.