The results demonstrated that the differential cytokines were significantly enriched in mainly four pathways including cytokine-cytokine receptor interaction (P = 1.33E-20), viral protein interaction with cytokine and cytokine receptor (P = 5.23E-14), JAK-STAT signaling pathway (P = 2.34E-10) and rheumatoid arthritis(RA) (P = 1.45E-10). Here, SOAT1 is linked to rheumatoid arthritis.