In a recent study of T-cell depleted allo-HSCT, sIL2-Rα, in combination with four other markers (elafin, REG3-α, sTNFR-1, and HGF), were included in a scoring system that correlated with a-GVHD severity (9); however, despite the high sensitivity of sIL2-Rα as a predictor of GVHD and TRM, it yielded low specificity. The gene discussed is PI3; the disease is graft versus host disease.