GBP1 and breast cancer: In a study of human breast cancer samples, Fekete and Györffy (57) found that GBP1 expression strongly correlated with paclitaxel treatment failure across all molecular subtypes of breast cancer, although this is in contradiction to findings from Tipton et al. (58) using genetic manipulation of GBP1 in human cell lines that found GBP1 over-expression did not induce paclitaxel resistance.