SQSTM1 and infection: The exact relationships between GBP1 binding partners and its diverse cellular effects are incompletely characterized, although it has been shown that GBP1 interaction with p62 at the endosome surface is necessary for maturation into autophagosomes in the clearance of intracellular infections in monocytes and that GBP1 interacts with the actin cytoskeleton in reducing the response to inflammatory stimuli in T-cells.