GBP1 and infection: Elucidation of these and other questions, such as the identity of other factors cooperating with GBP1 in membrane trafficking, TXR, and cell stress response, will yield rich new insights into the regulation of inflammation, cell survival in the face of cytotoxic stressors, the progression of myriad forms of cancer, and the therapeutic means to alter GBP1-related activities to improve control of infection, cancer, inflammation, and senescence.