Based on our review, we propose that 13 of these biomarkers require special attention, due to the concordance between expression and/or methylation status in infected children, data in adults (with H. pylori-induced gastritis and gastric cancer) and their consistent role in carcinogenesis (Tables 1–3): β-catenin, C-MYC, GATA-4, DAPK1, CXCL13, DC-SIGN, TIMP3, EGFR, GRIN2B, PIM2, SLC5A8, CDH1, and VCAM-1. The gene discussed is PIM2; the disease is gastric cancer.