GRIN2B (Glutamate Ionotropic Receptor NMDA Type Subunit 2B) codifies for a glutamate receptor expressed on the surface of cancer cells (Deutsch et al., 2014), and its hypermethylation and silencing have been reported in several solid tumors, including GC (Kim et al., 2006; Liu et al., 2007; Kang et al., 2008; Tamura et al., 2011). This evidence concerns the gene GRIN2B and gastric cancer.