Wang et al. (2010) described that LCN2 overexpression in GC is associated with low survival. Obayashi et al. (2016) postulated that LCN2 overexpression due to H. pylori infection in children, demonstrated both in epithelial cells and inflammatory cells in gastric epithelium, may interfere with iron uptake and proliferation of the bacterium, thereby protecting infected gastric mucosa from carcinogenesis. This evidence concerns the gene LCN2 and gastric cancer.