STAT2 and Flavivirus Infections: Notably, flavivirus infection appears to trigger proteasomal targeting and degradation of a variety of innate antiviral immune proteins: the most well-studied being the binding of DENV NS5 to STAT2, resulting in the ubiquitination and degradation of STAT2 and reduction in the type 1 interferon response (Ashour et al., 2009, 2010; Mazzon et al., 2009).