Flavivirus infection has been shown to activate several arms of the UPR, suggesting that SIAH1 expression may be induced in cells infected with DENV2 (Medigeshi et al., 2007; Pena et al., 2011; Pena and Harris, 2012; Scortegagna et al., 2014). The gene discussed is SIAH1; the disease is Flavivirus Infections.