This hypothesis has been indirectly confirmed by Jayasena et al. (30), who demonstrated an association between ischemic heart disease and a high GH burden (calculated for each patient by multiplying the number of years of disease duration by the mean level of GH recorded during the entire follow-up), and between cerebrovascular disease/cardiomyopathy and a higher mean IGF-1 burden (calculated similarly to the GH burden, using the mean IGF-1 index). This evidence concerns the gene IGF1 and cerebrovascular disorder.