Importantly, skeletal phenotypes were described for Fam20c (non-lethal Raine syndrome), Lrrk1 (osteosclerotic metaphyseal dysplasia), Pappa2 (short stature), Sfrp4 (Pyle's disease), and Slc10a7 (skeletal dysplasia) prior to knowledge of the human skeletal dysplasias when mutated in humans (84). The gene discussed is FAM20C; the disease is skeletal dysplasia.