Hypophosphatasia occurs in sheep (118) and dogs (119) having mutations in ALPL. Canine genetic skeletal disorders include mutations in ADAMTSL2—geleophysic dysplasia (120), COL1A2—osteogenesis imperfecta (121), DVL2—Robinow syndrome (122), HES7—spondylocostal dysostosis (123), and SERPINH1—osteogenesis imperfecta (124). Here, DVL2 is linked to osteogenesis imperfecta.