Importantly, skeletal phenotypes were described for Fam20c (non-lethal Raine syndrome), Lrrk1 (osteosclerotic metaphyseal dysplasia), Pappa2 (short stature), Sfrp4 (Pyle's disease), and Slc10a7 (skeletal dysplasia) prior to knowledge of the human skeletal dysplasias when mutated in humans (84). Here, LRRK1 is linked to skeletal dysplasia.