A randomized, prospective, 24-week, Phase III study (PAOLA) showed that long-acting pasireotide had superior efficacy (in achieving GH <2.5 μg/L and IGF-I below the upper limit of normal [ULN]) vs. continued treatment with long-acting octreotide or lanreotide in patients with uncontrolled acromegaly despite ≥6 months of treatment (19). This evidence concerns the gene GH1 and acromegaly.