CDKL5 and Rett syndrome: The prognosis of epileptic spasms is generally devastating and is associated with poor neurodevelopmental and behavioral outcomes, particularly in some patients with an underlying genetic etiology such as in CDKL5 encephalopathy, a rare X-linked genetic disorder, and CDKL5 genetic changes or mutations have been found in children diagnosed with infantile spasms, Lennox-Gastaut Syndrome, Rett Syndrome, West Syndrome (12).