Autoantibodies to LGI1 (LGI1-Abs) are the most common autoantibody in patients with limbic encephalitis (LE), a clinical syndrome characterized by the acute development of mood changes, anxiety, short-term memory deficit, and seizures due to an inflammatory process involving the limbic system that includes the medial temporal lobes, hippocampus, amygdala, and frontobasal and cingulate cortices (1). This evidence concerns the gene LGI1 and mood disorder.