Jia et al. (2016) showed increased CLIC1 expression in pancreatic ductal adenocarcinoma correlating higher expression with higher histological grade and increased tumor size. Two independent groups have shown that in hepatocellular carcinoma CLIC1 is overexpressed (Song et al., 2010), and, surprisingly, down-regulation of CLIC1 enhanced the proliferative activity and blocked apoptosis (Li et al., 2012). In studies focused on cell cycle, IAA-94, a CLIC blocker (Valenzuela et al., 2000) was shown to arrest cells at the G2-M phase linking CLICs to the cell cycle. Here, CLIC1 is linked to hepatocellular carcinoma.