Several members of the CLIC family, CLIC1 to CLIC6, located in various organelles of the cells (Figure 1) are implicated in physiological roles and pathological conditions, such as cancer initiation and progression in multiple studies (Peretti et al., 2014; Flores-Tellez et al., 2015; Hernandez-Fernaud et al., 2017), pulmonary hypertension (Wojciak-Stothard et al., 2014), hearing (Gagnon et al., 2006; Seco et al., 2015), Alzheimer’s disease (Novarino et al., 2004; Milton et al., 2008) and cardiac dysfunction (Takano et al., 2012). This evidence concerns the gene CLIC1 and Alzheimer disease.