CLIC1 is overexpressed in several cancers including liver cancer, gall bladder cancer, pancreatic ductal adenocarcinoma, glioma, breast cancer, nasopharyngeal carcinoma, and gastric cancer to name a few (Wulfkuhle et al., 2002; Petrova et al., 2008; Chang et al., 2009; Wang et al., 2009, 2018; Tang et al., 2012; Wei et al., 2015; Jia et al., 2016; Qu et al., 2016). This evidence concerns the gene CLIC1 and gallbladder cancer.