For example, the amount of cholesterol and the ratios of saturated to unsaturated fatty acids known to influence the biophysical properties of membranes have been shown to increase the interaction of APP with beta-secretase in early AD (Kametaka et al., 2003; Marlow et al., 2003; Avila-Munoz and Arias, 2015). The gene discussed is APP; the disease is Alzheimer disease.