DMP1 and X-linked hypophosphatemia: Given the clinical similarities between XLH and ARHR1, the biological relationship between PHEX and DMP1 (Martin et al., 2011), and DMP1’s involvement in odontoblast differentiation and dentin matrix mineralization (George et al., 1995; Narayanan et al., 2003; Wu et al., 2011), we explore DMP1’s ability to restore physiological proteolytic events resulting in mineralization of XLH dentin.