Simultaneous inhibition of HGF and c-MET combined with gemcitabine is more effective in reduction of tumor volume in an orthotopic model of pancreatic cancer than chemotherapy alone, indicating a critical role of the HGF/c-MET pathway in PSC–cancer cell interactions (Pothula et al., 2017). The gene discussed is HGF; the disease is familial pancreatic carcinoma.