Another plausible anti-fibrotic and mechanomodulatory strategy against pancreatic diseases could be targeting YAP and TAZ signal transduction of the Hippo pathway: YAP/TAZ, via their interaction with the cell cytoskeleton, promote cell “stemness,” tissue regeneration, and remodeling of the stroma; whereas YAP can modulate fibroinflammatory responses (Martinez et al., 2019). This evidence concerns the gene YAP1 and pancreas disorder.