The investigation of KEGG pathways demonstrated that the top 14 significant pathways were HTLV-1 infection, proteoglycans in cancer, systemic lupus erythematosus, ubiquitin-mediated proteolysis, amoebiasis, Chagas disease, hippo signaling pathway, malaria, pathways in cancer, regulation of actin cytoskeleton, intestinal immune network for IgA production, nucleotide excision repair, WNT signaling pathway, and Jak-STAT signaling pathway (adjusted P < 0.05, Figure 4 and Supplementary Table 2). This evidence concerns the gene SOAT1 and systemic lupus erythematosus.