Resveratrol (RES) can interact with mutant SOD1 (G93A) protein (a distinctive feature of ALS) (Julien, 2007; Srinivasan and Rajasekaran, 2018; Laudati et al., 2019) and has positive effects by up-regulating sirtuin 1 (SIRT1) expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of ALS (Wang J. et al., 2011) (Table 1). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.