In addition, oxidative damage results in the aggregation of TDP-43, the major disease-associated protein involved in the pathogenesis of ALS (Moujalled et al., 2017; Oberstad et al., 2018) that promotes OS in neuronal cells (Duan et al., 2010; Cohen et al., 2012, 2015; Magrané et al., 2014) (Figure 1). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.