CASP3 and amyotrophic lateral sclerosis: Treatment with EGCG could delay the outbreak or progression of ALS through changes in intracellular signals, increases survival signals (like PI3-K and Akt) and reduces death signals (like GKS-3ß, cytosolic cytochrome c, activated caspase-3 and cleaved poly ADP-ribose polymerase) (Levites et al., 2002; Mandel et al., 2003, 2005; Koh et al., 2006) (Table 1).