For this reason, the therapeutic strategy based on nutritional supplementation with NR could be of interest in AD cases to stop the onset and progression of the dementia (Rodgers et al., 2005) and to improve cognitive function and synaptic plasticity by promoting the function of PGC-1α as demonstrated in Tg2576 mice (mouse model of ALS) (Gong et al., 2013). Here, PPARGC1A is linked to Alzheimer disease.