GJA1 and myocardial infarction: Furthermore, the deficiency of gap-junctional proteins, localized in intercalated disks especially including Cx43, aggravated disrupted cardiac remodeling in post-myocardial infarction and directly increased the risk of fatal arrhythmias (Severs, 2002; Van Rijen et al., 2004; Yanni et al., 2011).