Single nucleotide polymorphisms (SNPs) in MMP2 (rs243865), MMP9 (rs17576), MMP13 (rs2252070), and TIMP2 (rs7501477) were investigated for their association with caries in 505 subjects, 212 caries-free subjects and 293 subjects presenting with dental caries. The gene discussed is TIMP2; the disease is dental caries.