ELN and pulmonary arterial hypertension: Using the calibrated framework, we have created three cases to simulate progressive pathological changes associated with PAH in the (1) large pulmonary arteries (increase in collagen mass and degradation of elastin) (Wang et al., 2013), (2) RV (decrease in contractility due to right ventricular failure) (Naeije and Manes, 2014), and (3) pulmonary microcirculation (increase in resistance due to remodeling) (Kobs et al., 2005).