CAMK2G and cardiac arrhythmia: As such, these inhibitors have been delivered through pharmacologic and genetic means to robustly inhibit CaMKII pathologic signaling in vitro and in vivo, mitigating HF, increasing cardiac function, and preventing lethal cardiac arrhythmias (Zhang et al., 2005; Khoo et al., 2006; Luo et al., 2013; Purohit et al., 2013).