Recent studies demonstrated that H2S inhibited reactive oxygen species (ROS) generation, NLRP3 inflammasome and apoptosis to improve endothelial dysfunction in spontaneously hypertensive rats, attenuate high glucose-induced human retinal pigment epithelial cell inflammation and attenuate pathogenesis of ozone-induced mice lung inflammation and emphysema (Li F. et al., 2016; Li et al., 2019; Wang et al., 2019). The gene discussed is NLRP3; the disease is pulmonary emphysema.