Variations in soluble epoxide hydrolase and ω-hydroxylase genes in human population also alter the risk of coronary heart disease, ischemic stroke, restenosis, diabetes heart, heart failure, ischemic stroke in Caucasians, Chinese, and in the African Americans with hypertension (Lee et al., 2006; Burdon et al., 2008; Monti et al., 2008; Kullmann et al., 2009; Fava et al., 2010; Zordoky and El-Kadi, 2010). Here, EPHX2 is linked to heart failure.