To comprehensively understand the effect of XZT on the SCF/c-kit signaling pathway, which plays a critical role in ICC functions, we tested the number and viability of ICCs and their electronic activities, in particular the signaling of mediator expression and phosphorylation, in vivo and in vitro with the inhibitor imatinib as the control. This evidence concerns the gene KIT and intrahepatic cholangiocarcinoma.