MC4R and Obesity: A meta-analysis has revealed that the genes of pharmacodynamic targets of antipsychotics like HTR2C, DRD2, ADRA2A and genes implicated in obesity such as MC4R, GNB3, FTO, LEP, LEPR, BDNF, and INSIG2 seem to be consistently relevant to antipsychotic-induced weight gain (Zhang et al., 2016).