Similarly, in another study, oral administration of WA (4 mg/kg) effectively inhibited HepG2-xenografts and diethylnitrosamine (DEN)-induced-hepatocellular carcinoma (HCC) in C57BL/6 mice by elevating the levels of ERK, RSK, ELK1, and DR5 along with decreased expression of Ki67. The gene discussed is MKI67; the disease is hepatocellular carcinoma.