CASP3 and neoplasm: Intraperitoneal administration of hispidulin (20 mg/kg) inhibited the Caki-2 (human clear cell renal cell carcinoma) tumor growth and lung metastasis in athymic BALB/c nu/nu mouse model by increasing the expression of cleaved caspase-3 and decreasing the activity of Sphk1, thereby modulating ceramide-S1P balance (Gao et al., 2017).