In another pilot study on 39 women at increased risk for breast cancer, trans-resveratrol (50 mg twice a day for 12 weeks) decreased methylation of Ras association domain family 1 isoform A (RASSF)-1a, a gene associated with breast cancer, increased levels of trans-resveratrol and resveratrol-glucuronide in the circulation, and decreased cancer promoting PGE2 expression in the breast (Zhu et al., 2012). The gene discussed is RASSF1; the disease is breast carcinoma.