Subtype SERCA2 was a key modulator of calcium cycling in both cardiomyocytes and vascular SMCs, and the pulmonary arterial SERCA2 expression is down-regulated in a rat monocrotaline model of PH as well as in humans with PAH (Sahoo et al., 2015). The gene discussed is ATP2A2; the disease is pulmonary arterial hypertension.