IGHE and inflammatory response: T-lymphocytes are often considered to express a distinctive pattern of cytokines, especially Th2 cytokines, which contribute to remodeling and AHR (Mosmann and Sad, 1996); whereas, Blymphocytes secrete IgE and the factors regulating IgE secretion, which result in recruiting inflammatory cells into the airways, eventually contributing to airway inflammation (Gould et al., 2000).