T-lymphocytes are often considered to express a distinctive pattern of cytokines, especially Th2 cytokines, which contribute to remodeling and AHR (Mosmann and Sad, 1996); whereas, Blymphocytes secrete IgE and the factors regulating IgE secretion, which result in recruiting inflammatory cells into the airways, eventually contributing to airway inflammation (Gould et al., 2000). Here, IGHE is linked to inflammation.