In particular, the missense substitution G2385R within the WD40 domain leads to a partial loss-of-function of LRRK2, and is pathologically relevant for PD, being associated with an increased risk of developing idiopathic PD in Chinese and Korean ethnicity (Tan et al., 2009; Carrion et al., 2017). Here, LRRK2 is linked to Parkinson disease.