LRRK2 and Parkinson disease: Dm carrying the LRRK2 loss-of-function mutation in the WD40 domain (LRRKWD40) is a simple in vivo model of PD that recapitulates key features of the disease, including motor impairment and mitochondrial abnormalities (Lee et al., 2012; De Rose et al., 2016; Hewitt and Whitworth, 2017).