Tabata et al. (2009) reported the secretion of an angiopoietin-like protein-2 by adipocytes and considered it as a marker of adiposity (Tabata et al., 2009). Ang-2 promotes vascularization of subcutaneous WAT and improves metabolic homeostasis, and it is therefore has a promising role in mitigating high-fat diet-induced obesity (An et al., 2017). The gene discussed is ANGPT2; the disease is obesity due to melanocortin 4 receptor deficiency.