Therefore, in this study, we selected 18 SNPs (FERMT2 rs17125924, HLA-DRB1 rs9271058 and rs6931277, CD2AP rs9473117, APH1B rs35408871, NDUFAF6 rs4735340, ADAMTS20 rs7295246, EPHA1 rs10808026 and rs11763230, ADAM10 rs593742 and rs442495, INPP5D rs10933431, PTK2B rs73223431, CR1 rs2093760, MS4A6A rs7935829, CLNK rs6448451, CD2AP-TNFRSF21 rs9381563, CLU rs4236673) from aforementioned studies, aiming to explore the relationship between these genes and AD risk in the southern Chinese population. Here, CD2AP is linked to Alzheimer disease.