In APOE ε4 carriers, the allele and genotype frequencies of FERMT2 rs17125924 were significantly different between AD patients and controls (allele: P = 0.029, OR = 1.895, 95% CI: 1.06–3.38; genotype: P = 0.036), with allele G found to be higher in the case group than in the control (Table 2). Here, APOE is linked to Alzheimer disease.