We believe that disturbed homeostasis of Na+, K+-ATPase plays a key role in the pathophysiology of migraine (Gross et al., 2019), as many regulators of Na+, K+-ATPase, such as estrogen, adrenaline, insulin (Matsuda et al., 1993; Therien and Blostein, 2000), dopamine (Nishi et al., 1999; Hazelwood et al., 2008), glutamate (Nathanson et al., 1995), etc. are involved in the pathophysiology of migraine (see Harrington et al., 2010 for a comprehensive review). Here, INS is linked to migraine disorder.